gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CAR-T cells kill Claudin18.2+ tumor cells via perforin/granzyme; the iPD-1 feature counters PD-1/PD-L1 inhibition to enhance this killing but does not target or directly kill PD-L1+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
engaged via iPD-1 module to counter checkpoint inhibition
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05952375
disease_id_num_tar_ref
3616
drug_id_num_tar_ref
9825