gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Glofitamab engages CD3 on T cells to activate them and crosslink to CD20 on B cells; activated T cells kill CD20+ cells via perforin/granzyme. CD3+ T cells are not the cytotoxic targets.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
binds CD3ε on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05833763
disease_id_num_tar_ref
3625
drug_id_num_tar_ref
9851