gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CD20 on B cells and triggers FcγRIIIa-mediated ADCC and antibody-dependent phagocytosis (ADCP), and also induces caspase-independent direct cell death (type II anti-CD20).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20 binding; glycoengineered Fc enhances FcγRIIIa engagement for ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05833763
disease_id_num_tar_ref
3625
drug_id_num_tar_ref
9852