gene_symbol
IFNAR2
hgnc_id
HGNC:5433
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug targets CD38, not IFNAR2. After binding CD38, its IFN-α payload engages IFNAR1/2 to activate JAK–STAT and induce antiproliferative/apoptotic effects in CD38+ cells; IFNAR2-only cells are not specifically targeted and may only be affected via bystander IFN signaling.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engaged by attenuated IFN-α moiety
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05590377
disease_id_num_tar_ref
3634
drug_id_num_tar_ref
9876