gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2 on tumor cells, is internalized, and releases a camptothecin-derived topoisomerase I inhibitor that stabilizes TOP1–DNA complexes, causing DNA damage, replication arrest, and apoptosis.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase; ADC antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05924256
disease_id_num_tar_ref
3645
drug_id_num_tar_ref
9896