gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HER2-directed ADC binds HER2, is internalized, and releases a camptothecin-derived TOP1 inhibitor that traps TOP1–DNA complexes, causing DNA damage, replication arrest, and apoptosis in the targeted cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular payload target (camptothecin-derived TOP1 inhibitor, rezetecan)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05924256
disease_id_num_tar_ref
3645
drug_id_num_tar_ref
9896