gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds TROP2, is internalized, linker is cleaved, and an exatecan-derived topoisomerase I inhibitor is released inside the cell, blocking DNA replication and inducing cell-cycle arrest and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antigen target (cell-surface transmembrane glycoprotein)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05924256
disease_id_num_tar_ref
3645
drug_id_num_tar_ref
9899