gene_symbol
FAS
hgnc_id
HGNC:11920
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Antigen-specific CTLs recognize peptide–MHC via the TCR and then deliver a lethal hit; FasL on CTLs engages Fas (CD95) on the target to trigger extrinsic apoptosis (caspase-8), with perforin/granzyme also contributing. Fas is an effector receptor, not the recognition target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engaged by CTL-expressed Fas ligand (FASLG) to trigger apoptosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06296056
disease_id_num_tar_ref
302
drug_id_num_tar_ref
863