gene_symbol
TNFRSF10A
hgnc_id
HGNC:11904
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antigen-specific CTLs recognize peptide–MHC I on targets, then kill via perforin/granzyme and by engaging DR4 with TRAIL to trigger extrinsic (caspase-mediated) apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engaged by CTL-derived TRAIL (TNFSF10) to induce apoptosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06296056
disease_id_num_tar_ref
302
drug_id_num_tar_ref
863