gene_symbol
CLEC12A
hgnc_id
HGNC:31713
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-engineered NK cells bind CLEC12A (CLL-1) and, upon CAR engagement, directly kill target cells via NK degranulation with perforin/granzyme-mediated apoptosis and cytotoxic cytokine release.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06307054
disease_id_num_tar_ref
3666
drug_id_num_tar_ref
9948