gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds HER2, is internalized, and releases MMAE, which binds the vinca domain of beta‑tubulin to block microtubule polymerization, causing mitotic arrest and apoptosis. Beta‑tubulin is the payload’s intracellular target, not the antigen used for targeting.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Direct target of MMAE payload; inhibits microtubule polymerization across beta-tubulin isotypes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05912816
disease_id_num_tar_ref
3667
drug_id_num_tar_ref
9949