gene_symbol
TNFRSF10B
hgnc_id
HGNC:11905
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antigen-specific CTLs recognize tumor peptide–MHC I via the TCR and kill targets via perforin/granzyme release and by engaging TRAIL on CTLs with DR5 (TRAIL‑R2) on the tumor, triggering extrinsic apoptosis (caspase-8).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engaged by CTL-derived TRAIL (TNFSF10) to induce apoptosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06296056
disease_id_num_tar_ref
302
drug_id_num_tar_ref
863