gene_symbol
CD79B
hgnc_id
HGNC:1699
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CD79b on B cells, is internalized, linker cleaved to release MMAE, which inhibits tubulin polymerization causing G2/M arrest and apoptosis of CD79b+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface BCR component targeted by the ADC antibody moiety
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06071871
disease_id_num_tar_ref
3684
drug_id_num_tar_ref
9981