gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Polatuzumab vedotin targets CD79b on B cells, is internalized, and releases MMAE, which binds beta-tubulin to disrupt microtubes, causing G2/M arrest and apoptosis. Beta-tubulin is the payload’s intracellular target, not the drug’s direct targeting antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of the released MMAE payload; multiple TUBB isoforms may be engaged
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06071871
disease_id_num_tar_ref
3684
drug_id_num_tar_ref
9981