gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its afucosylated Fc engages FcγRIIIa on NK cells/macrophages to drive ADCC/ADCP and it also induces direct, caspase‑independent B‑cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20; binds extracellular domain on B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06071871
disease_id_num_tar_ref
3684
drug_id_num_tar_ref
9982