gene_symbol
SIGLEC2
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD22 ADC binds CD22 on B cells, is internalized, and releases calicheamicin intracellularly, which induces DNA double-strand breaks leading to apoptosis of CD22+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell-restricted receptor; rapid internalization enables payload delivery
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05687032
disease_id_num_tar_ref
3686
drug_id_num_tar_ref
9985