gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD47–SIRPα blockade removes the “don’t eat me” signal, enabling macrophage Fc/CR-dependent antibody-dependent cellular phagocytosis (ADCP) of CD47+ tumor cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
innate immune checkpoint ligand ('don’t eat me' signal)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06585059
disease_id_num_tar_ref
305
drug_id_num_tar_ref
868