gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 Fc of cetuximab engages Fcγ receptors on NK cells and other effectors to mediate ADCC (and ADCP/CDC), directly killing EGFR-expressing cells; EGFR blockade also inhibits proliferation.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III), blocking ligand binding and receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06274437
disease_id_num_tar_ref
3700
drug_id_num_tar_ref
10025