gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD19-specific CAR-T cells bind CD19 on target cells and kill them via T-cell cytotoxicity (perforin/granzyme-mediated apoptosis, with possible Fas/FasL signaling).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
HLA-independent CAR binding to the CD19 extracellular domain on B-lineage cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06569472
disease_id_num_tar_ref
3707
drug_id_num_tar_ref
10034