gene_symbol
CCR8
hgnc_id
HGNC:1609
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CCR8 mAb binds CCR8 on Tregs; its Fc engages FcγR on NK cells (and other effectors) to trigger ADCC (and ADCP), leading to depletion of CCR8+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Expressed on tumor-infiltrating regulatory T cells; selective depletion via ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06304571
disease_id_num_tar_ref
3709
drug_id_num_tar_ref
10038