gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HC006 binds CCR8 on Tregs and uses its Fc to engage CD16a on NK cells to trigger ADCC, killing CCR8+ Tregs; CD16a+ effector cells are not the targets and are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated effector engagement for ADCC (primarily on NK cells)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06304571
disease_id_num_tar_ref
3709
drug_id_num_tar_ref
10038