gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD19 ADC binds CD19, is internalized, and releases a PBD dimer (tesirine) via a cleavable linker that forms DNA interstrand crosslinks, blocking replication and inducing apoptosis in CD19+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B-cell antigen targeted by the antibody component; internalization enables payload delivery
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05658562
disease_id_num_tar_ref
3710
drug_id_num_tar_ref
10039