gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the KRAS G12V neoantigen peptide presented on HLA-A on tumor cells and induce MHC-restricted killing via perforin/granzyme release (and Fas–FasL), causing apoptosis/lysis.
enzyme_product
On
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide presented on HLA-A (MHC class I); allele-specific restriction
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05438667
disease_id_num_tar_ref
3724
drug_id_num_tar_ref
10066