gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Engineered TCR-T cells kill only when mutant KRAS G12V/G12D peptides are presented by HLA-A; recognition of the peptide–HLA complex triggers perforin/granzyme-mediated cytolysis. HLA-A expression alone is not sufficient.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Component of peptide–MHC complex recognized by engineered TCR; allele-specific
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05438667
disease_id_num_tar_ref
3724
drug_id_num_tar_ref
10066