gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD19 IgG1 binds CD19 on B-lineage cells and recruits FcγR-expressing effector cells to mediate antibody-dependent cellular cytotoxicity (and phagocytosis), depleting CD19+ cells; complement activation may also contribute.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane antigen on B-lineage cells including plasmablasts
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06497374
disease_id_num_tar_ref
3725
drug_id_num_tar_ref
10072