gene_symbol
TNF
hgnc_id
HGNC:11892
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The IgG1 antibody binds transmembrane TNF on cells and can trigger apoptosis via reverse signaling and mediate Fc-dependent ADCC/CDC by effector cells/complement, killing TNF-expressing immune cells (neutralization of soluble TNF does not kill cells).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds both soluble and transmembrane forms to neutralize TNFR1/2 signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06064864
disease_id_num_tar_ref
3733
drug_id_num_tar_ref
10095