gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DNA vaccine primes CMV IE1-specific CD8+ T cells that recognize IE1 peptides on MHC I of CMV-expressing tumor cells and lyse them via perforin/granzyme-mediated cytotoxicity (with CD4+ T-cell help).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
HCMV gene UL123; delivered as IE1-pp65 fusion antigen; fused to human LAMP1 for lysosomal targeting
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05698199
disease_id_num_tar_ref
3735
drug_id_num_tar_ref
10099