gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DNA vaccine primes APCs to present pp65, inducing pp65-specific CD8+ T cells that recognize pp65 peptides on MHC I of tumor cells and kill them via perforin/granzyme CTL mechanisms (with CD4+ T-cell help).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
HCMV gene UL83; delivered as IE1-pp65 fusion antigen; fused to human LAMP1 for lysosomal targeting
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05698199
disease_id_num_tar_ref
3735
drug_id_num_tar_ref
10099