gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds TROP2 on tumor cells, is internalized, and releases the TOP1 inhibitor exatecan, causing DNA damage, S-phase arrest, and apoptosis of TROP2-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC cell-surface antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06480240
disease_id_num_tar_ref
3742
drug_id_num_tar_ref
10116