gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds TROP2 on tumor cells, is internalized, and releases exatecan; the payload inhibits TOP1 in those cells, causing DNA damage, S-phase arrest, and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cytotoxic payload target (exatecan)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06480240
disease_id_num_tar_ref
3742
drug_id_num_tar_ref
10116