gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific antibody binds BCMA on target cells and CD3 on T cells, crosslinking to activate TCR/CD3 signaling and T-cell degranulation, leading to perforin/granzyme-mediated lysis of BCMA-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated antigen on malignant plasma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06171685
disease_id_num_tar_ref
3747
drug_id_num_tar_ref
10126