gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Irreversible inhibition of mutant EGFR kinase (including T790M) suppresses MAPK/PI3K-AKT signaling, leading to apoptosis of EGFR-dependent tumor cells while relatively sparing wild-type EGFR.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Mutant-selective EGFR inhibition, including T790M and common activating mutations (e.g., L858R, exon 19 deletion); irreversible covalent binding at C797 in the ATP site
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05847764
disease_id_num_tar_ref
3751
drug_id_num_tar_ref
10135