gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blinatumomab binds CD3ε on T cells and CD19 on B cells to form an immune synapse, activating T cells to release perforin/granzyme and kill CD19+ cells; CD3+ T cells are effectors, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell engaging arm; epsilon chain of CD3 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06054113
disease_id_num_tar_ref
3754
drug_id_num_tar_ref
10139