gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets HER2, not tubulin. After HER2-mediated internalization, MMAE is released and binds beta-tubulin to disrupt microtubules, causing G2/M arrest and apoptosis; Fc-mediated ADCC may contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload MMAE binds the Vinca site on beta-tubulin to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06074484
disease_id_num_tar_ref
3755
drug_id_num_tar_ref
10140