gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CD19 on B cells, is internalized, and releases a cytotoxic payload that damages DNA or microtubules to induce apoptosis; Fc-mediated ADCC/CDC may also contribute.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen targeted by some ADCs used in R/R DLBCL (e.g., loncastuximab tesirine)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05883709
disease_id_num_tar_ref
3761
drug_id_num_tar_ref
10160