gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2 subdomain II and blocks HER2 dimerization, inhibiting downstream signaling and promoting apoptosis; its IgG1 Fc engages FcγR-bearing effector cells to mediate ADCC against HER2-expressing cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks HER2 homodimerization and heterodimerization with other ERBB receptors (e.g., ERBB3).
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06197581
disease_id_num_tar_ref
3767
drug_id_num_tar_ref
10177