gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Glofitamab binds CD3ε on T cells to activate and redirect them; the activated T cells kill CD20+ B cells via perforin/granzyme, not the CD3ε-expressing T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T cell receptor-CD3 complex component; single CD3-binding domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06682130
disease_id_num_tar_ref
316
drug_id_num_tar_ref
899