gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Avelumab’s Fc binds CD16a on NK cells to activate them for ADCC against PD‑L1–expressing targets; CD16a+ cells are effectors, not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated NK-cell ADCC engagement
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06018116
disease_id_num_tar_ref
3778
drug_id_num_tar_ref
10206