gene_symbol
TP53
hgnc_id
HGNC:11998
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
DC vaccine primes/expands p53-specific CD8+ T cells; CTLs recognize p53-derived peptides on MHC I of tumor cells and kill them via perforin/granzyme (and Fas–FasL) apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MHC I/II-presented peptide epitope from tumor-associated antigen
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06015269
disease_id_num_tar_ref
3783
drug_id_num_tar_ref
10217