gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The bispecific antibody binds CD3 on T cells to activate and redirect them toward KLK2-expressing tumor cells; activated T cells mediate perforin/granzyme-dependent lysis of KLK2+ tumor cells. CD3+ cells (T cells) are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target is the T-cell CD3 receptor complex; specific subunit not explicitly stated in trial materials
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05818683
disease_id_num_tar_ref
3786
drug_id_num_tar_ref
10219