gene_symbol
FCGRT
hgnc_id
HGNC:3621
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
3BNC117-LS binds FcRn via engineered Fc in endosomes to extend antibody half-life; this interaction does not recruit effector functions or complement. Any cytotoxicity is directed at HIV Env-expressing cells via ADCC/ADCP, not at FcRn-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
LS Fc mutations increase FcRn affinity and extend half-life
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05079451
disease_id_num_tar_ref
3796
drug_id_num_tar_ref
10257