gene_symbol
FCGR3B
hgnc_id
HGNC:3620
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its Fc engages Fcγ receptors (e.g., CD16a on NK cells and CD16b on neutrophils) to mediate ADCC/ADCP against CD20+ B cells and also induces direct B‑cell death. CD16b+ cells act as effectors, not targets, and are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc–Fc receptor interaction contributing to effector function
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06682130
disease_id_num_tar_ref
316
drug_id_num_tar_ref
900