gene_symbol
ERBB3
hgnc_id
HGNC:3431
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds HER3 on tumor cells, is internalized, and releases a camptothecin-class topoisomerase I inhibitor payload that inhibits topoisomerase I, causing DNA damage and tumor cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor; ADC bispecific arm binds HER3
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05785039
disease_id_num_tar_ref
3803
drug_id_num_tar_ref
10270