gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Ofatumumab binds CD20 on B cells, triggers complement-dependent cytotoxicity (CDC) and Fc-mediated ADCC/ADCP by NK cells/macrophages, and can induce apoptosis of the bound cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds a membrane-proximal extracellular epitope on CD20 expressed on B lymphocytes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05634967
disease_id_num_tar_ref
3811
drug_id_num_tar_ref
10286