gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Mogamulizumab binds CCR4 on target cells; its Fc engages FcγRIIIa (CD16a) on NK cells to trigger ADCC that kills CCR4+ cells. CD16a-expressing cells are effectors, not the cells killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement for ADCC; defucosylated IgG1 enhances affinity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06285370
disease_id_num_tar_ref
3813
drug_id_num_tar_ref
10289