gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
B7-H3-specific CAR T cells bind B7-H3 on target cells, activate, and directly kill them via perforin/granzyme-mediated cytolysis (and Fas/FasL), with cytokine release.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Also known as CD276; cell-surface antigen overexpressed on pleural tumors
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06726564
disease_id_num_tar_ref
3815
drug_id_num_tar_ref
10291