gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD19-directed CAR T cells bind CD19 on target cells, become activated, and kill via perforin/granzyme cytotoxicity (and Fas/FasL apoptosis), depleting CD19+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B-cell antigen; CAR scFv binds an extracellular epitope (e.g., FMC63-derived).
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05621096
disease_id_num_tar_ref
3828
drug_id_num_tar_ref
10323