gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD38 IgG1 mAb binds CD38 on target cells and induces Fc-mediated ADCC (NK cells) and ADCP (macrophages), complement-dependent cytotoxicity (CDC), and can trigger direct apoptosis upon crosslinking.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II transmembrane ectoenzyme (NADase/ADP-ribosyl cyclase)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06358638
disease_id_num_tar_ref
3834
drug_id_num_tar_ref
10338