gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BCMA-specific CAR T cells bind BCMA on target cells; CAR signaling activates the T cells to kill via perforin/granzyme release and death-receptor pathways.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Commercial BCMA-directed CAR T used for multiple myeloma
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05909059
disease_id_num_tar_ref
3839
drug_id_num_tar_ref
10349