gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BH3-mimetic inhibition of BCL-2 releases pro-apoptotic factors, activates BAX/BAK, induces mitochondrial outer membrane permeabilization and caspase-dependent apoptosis in BCL-2–dependent cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds BH3-binding groove (BH3 mimetic)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06384261
disease_id_num_tar_ref
3855
drug_id_num_tar_ref
10405